Professor Seth G.N. Grant FRSE
Centre for Clinical Brain Sciences
49 Little France Crescent
Seth Grant graduated from Sydney University with a Bachelor of Science (Medicine) degree based on research in respiratory neurophysiology with Dr. D.J.C. Read in 1980.
He graduated with Bachelor of Medicine and Bachelor of Surgery with First Class Honours in 1984 and also conducted respiratory physiology research at the Royal Free Hospital London with Dr. S.W. Clarke in 1981 and 1983.
From 1985-1989 he was a Postdoctoral Fellow at Cold Spring Harbor Laboratory (New York) with Dr. D.Hanahan studying transgenic mouse models of cancer and diabetes.
As a research associate at the Howard Hughes Medical Institute (1989-1994) and Centre for Neurobiology and Behavior at Columbia University (New York) he studied mouse genetic models of learning and memory with Dr. E.R. Kandel (Nobel Laureate in Medicine and Physiology, 2000).
He established his laboratory at the Centre for Genome Research at Edinburgh University in 1994 and in 2000 was appointed Professor of Molecular Neuroscience in the Division of Neuroscience. In 2003 he was appointed Principal Investigator at the Wellcome Trust Sanger Institute in Cambridge and remained there until 2011, when he returned to Edinburgh University.
He has held additional appointments including the John Cade Visiting Professor at Melbourne University (2005), Honorary Professorship at Cambridge University (2007 onward) and elected Fellow of the Royal Society of Edinburgh (2011).
The long-term aim is to understand the fundamental mechanisms of behaviour and how these mechanisms are involved in brain disease.
The research has focussed on the study of genes and proteins that control the synapses between nerve cells. Multiprotein machines comprising many different protein components are responsible for basic innate and learned behaviours and dysfunction in many brain diseases. Recent work shows that these mechanisms are conserved between mice and humans opening new avenues for diagnosis and therapeutic discoveries.
The Genes to Cognition research team (www.genes2cognition.org) has generated a large amount of data and tools that are freely available and an education and public understanding website (www.G2COnline.org).
The Grant lab is currently funded by The Wellcome Trust, Medical Research Council and European Union (GENCODYS, EUROSPIN, SYNSYS, Human Brain Project)
Bayes A, Collins MO, Galtrey CM, Simonnet C, Roy M, Croning MD, Gou G, van de Lagemaat LN, Milward D, Whittle IR, Smith C, Choudhary JS, Grant SG. Human post-mortem synapse proteome integrity screening for proteomic studies of postsynaptic complexes. Mol Brain. 2014;7:88.4271336 PMCID: PMC4271336
Fromer M, Pocklington AJ, Kavanagh DH, Williams HJ, Dwyer S, Gormley P, Georgieva L, Rees E, Palta P, Ruderfer DM, Carrera N, Humphreys I, Johnson JS, Roussos P, Barker DD, Banks E, Milanova V, Grant SG, Hannon E, Rose SA, Chambert K, Mahajan M, Scolnick EM, Moran JL, Kirov G, Palotie A, McCarroll SA, Holmans P, Sklar P, Owen MJ, Purcell SM, O'Donovan MC. De novo mutations in schizophrenia implicate synaptic networks. Nature. 2014;506(7487):179-84 PMCID:PMC4237002
Hill WD, Davies G, van de Lagemaat LN, Christoforou A, Marioni RE, Fernandes CP, Liewald DC, Croning MD, Payton A, Craig LC, Whalley LJ, Horan M, Ollier W, Hansell NK, Wright MJ, Martin NG, Montgomery GW, Steen VM, Le Hellard S, Espeseth T, Lundervold AJ, Reinvang I, Starr JM, Pendleton N, Grant SG, Bates TC. Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins. Transl Psychiatry. 2014;4:e341 PMCID: PMC3905224
Nithianantharajah J, Grant SG. Cognitive components in mice and humans: combining genetics and touchscreens for medical translation. Neurobiol Learn Mem. 2013;105:13-9 PMID:23796634
Nithianantharajah J, Komiyama NH, McKechanie A, Johnstone M, Blackwood DH, St Clair D, Emes RD, van de Lagemaat LN, Saksida LM, Bussey TJ, Grant SG. Synaptic scaffold evolution generated components of vertebrate cognitive complexity. Nat Neurosci. 2013;16(1):16-24 PMCID: PMC4131247
von Eichborn J, Dunkel M, Gohlke BO, Preissner SC, Hoffmann MF, Bauer JM, Armstrong JD, Schaefer MH, Andrade-Navarro MA, Le Novere N, Croning MD, Grant SG, van Nierop P, Smit AB, Preissner R. SynSysNet: integration of experimental data on synaptic protein-protein interactions with drug-target relations. Nucleic Acids Res. 2013;41(Database issue):D834-40.PMC3531074 PMCID:PMC3531074
Emes RD, Grant SG. Evolution of synapse complexity and diversity. Annu Rev Neurosci. 2012;35:111-31 PMID: 22715880
Hawrylycz MJ, Lein ES, Guillozet-Bongaarts AL, Shen EH, Ng L, Miller JA, van de Lagemaat LN, Smith KA, Ebbert A, Riley ZL, Abajian C, Beckmann CF, Bernard A, Bertagnolli D, Boe AF, Cartagena PM, Chakravarty MM, Chapin M, Chong J, Dalley RA, Daly BD, Dang C, Datta S, Dee N, Dolbeare TA, Faber V, Feng D, Fowler DR, Goldy J, Gregor BW, Haradon Z, Haynor DR, Hohmann JG, Horvath S, Howard RE, Jeromin A, Jochim JM, Kinnunen M, Lau C, Lazarz ET, Lee C, Lemon TA, Li L, Li Y, Morris JA, Overly CC, Parker PD, Parry SE, Reding M, Royall JJ, Schulkin J, Sequeira PA, Slaughterbeck CR, Smith SC, Sodt AJ, Sunkin SM, Swanson BE, Vawter MP, Williams D, Wohnoutka P, Zielke HR, Geschwind DH, Hof PR, Smith SM, Koch C, Grant SG, Jones AR. An anatomically comprehensive atlas of the adult human brain transcriptome. Nature. 2012;489(7416):391-9 PMCID:PMC4243026
Kirov G, Pocklington AJ, Holmans P, Ivanov D, Ikeda M, Ruderfer D, Moran J, Chambert K, Toncheva D, Georgieva L, Grozeva D, Fjodorova M, Wollerton R, Rees E, Nikolov I, Lagemaat LN, Bayes A, Fernandez E, Olason PI, Bottcher Y, Komiyama NH, Collins MO, Choudhary J, Stefansson K, Stefansson H, Grant SG, Purcell S, Sklar P, O'Donovan MC, Owen MJ. De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia. Molecular psychiatry. 2012;17(2):142-53 PMCID:PMC3603134
Barnett MW, Watson RF, Vitalis T, Porter K, Komiyama NH, Stoney PN, Gillingwater TH, Kind PC. Synaptic Ras GTPase activiating protein regulates pattern formation in the trigeminal system of mice. The Journal of Neuroscience. 2006;26;5;1355-65. PMID 16452659
Porter K, Komiyama NH, Vitalis T, Kind PC, Grant SG. Differential expression of two NMDA receptor interacting proteins, PSD-95 and SynGAP durin mouse develoment. European Journal of Neuroscience 2005;21;2;351-62 PMID:15673435
Komiyama NH, Watabe AM, Carlisle HJ, Porter K, Charlesworth P, Monti J, Strathdee DJ, O'Carroll CM, Martin SJ, Morris RG, O Dell TJ, Grant SG. SynGAP regulates ERK/MARK signalling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor. The Journal of Neuroscience. 2002;22;22;9721-32 PMID:12427827